The Virtual Brain

Profound science.

Peer-reviewed.

If you've used The Virtual Brain software for your scientific publication, please use the paper below for your citation list:

P. Sanz Leon, S. A. Knock, M. Woodman, L. Domide, J. Mersmann, A. R. McIntosh, V. Jirsa

The Virtual Brain: a simulator of primate brain network dynamics

Frontiers in Neuroinformatics 7:10. doi: 10.3389/fninf.2013.00010

If you're using The Virtual Brain v2.2 or higher, please cite additionally this paper:

M. Schirner, L. Domide, D. Perdikis, P. Triebkorn, L. Stefanovski, R. Pai, P. Popa, B. Valean, J. Palmer, C. Langford, A. Blickensdörfer, M. van der Vlag, S. Diaz-Pier, A. Peyser, W. Klijn, D. Pleiter, A. Nahm, O. Schmid, M. Woodman, L. Zehl, J. Fousek, S. Petkoski, L. Kusch, M. Hashemi, D. Marinazzo, J.-F. Mangin, A. Flöel, S. Akintoye, B. C. Stahl, M. Cepic, E. Johnson, G. Deco, A. R. McIntosh, C. C. Hilgetag, M. Morgan, B. Schuller, A. Upton, C. McMurtrie, T. Dickscheid, J. G. Bjaalie, K. Amunts, J. Mersmann, V. Jirsa, P. Ritter

Brain simulation as a cloud service: The Virtual Brain on EBRAINS

NeuroImage 2022, doi.org/10.1016/j.neuroimage.2022.118973

For some of these publications, we provide video lectures and even sample code and demo data:

You can use these TVB EduCases to learn how to use the software and conduct your own research!

  • May

    2022

    Neuroimage

    https://doi.org/10.1016/j.neuroimage.2022.118973

    Schirner, Domide, Perdikis, Triebkorn, Stefanovski, Pai, Prodan, Valean, Palmer, Langford, Blickensdörfer, van der Vlag, Diaz-Pier, Peyser, Klijn, Pleiter, Nahm, Schmid, Woodman, Zehl, Fousek, Petkoski, Kusch, Hashemi, Marinazzo, Mangin, Flöel, Akintoye, Stahl, Cepic, Johnson, Deco, McIntosh, Hilgetag, Morgan, Schuller, Upton, McMurtrie, Dickscheid, Bjaalie, Amunts, Mersmann, Jirsa, Ritter

    Brain simulation as a cloud service: The Virtual Brain on EBRAINS

  • May

    2022

    Experimental Neurology (in press)

    doi: 10.1101/2021.05.05.442704

    Meier JM, Perdikis D, Blickensdörfer A, Stefanovski L, Liu Q, Maith O, Dinkelbach HÜ, Baladron J, Hamker FH, Ritter P

    Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain

  • Apr

    2022

    Alzheimer’s Dement. Transl. Res. Clin. Interv. (in press)

    doi: 10.1101/2021.02.27.433161

    Paul Triebkorn, Leon Stefanovski, Kiret Dhindsa, Margarita-Arimatea Diaz-Cortes, Patrik Bey, Konstantin Bülau, Roopa Kalsank Pai, Andreas Spiegler, Ana Solodkin, Viktor Jirsa, Randy McIntosh, Alzheimer's Disease Neuroimaging Initiative, Petra Ritter

    Brain simulation augments machine-learning-based classification of dementia

  • Feb

    2022

    eNeuro

    doi: 10.1523/ENEURO.0075-21.2022

    Tyler Good, Michael Schirner, Kelly Shen, Petra Ritter, Pratik Mukherjee, Brian Levine, and Anthony McIntosh

    Personalized connectome-based modeling in patients with semi-acute phase mild TBI: relationship to acute neuroimaging and 6-month follow-up.

  • Jan

    2022

    Neuroimage

    doi: 10.1016/j.neuroimage.2022.118928

    M Schirner; X Kong; T Yeo; G Deco, P Ritter

    Dynamic primitives of brain network interaction

  • Dec

    2022

    Preprint at BioRvix

    DOI: 10.1101/2021.12.30.474565

    Spase Petkoski, Petra Ritter, Viktor K. Jirsa

    White-matter degradation and dynamical compensation support age-related functional alterations in human brain

  • Nov

    2021

    Preprint at BioRxiv

    DOI: 10.1101/2021.02.27.433161

    Paul Triebkorn, Leon Stefanovski, Kiret Dhindsa, Margarita-Arimatea Diaz-Cortes, Patrik Bey, Konstantin Bülau, Roopa Pai, Andreas Spiegler, Ana Solodkin, Viktor Jirsa, Anthony Randal McIntosh, for the Alzheimer’s Disease Neuroimaging Initiative, Petra Ritter

    Brain simulation augments machine-learning-based classification of dementia

  • Sep

    2021

    Alzheimer’s & Dementia

    doi: 10.1002/alz.12311

    Claudio Babiloni, Xianghong Arakaki, Hamed Azami, Karim Bennys, Katarzyna Blinowska, Laura Bonanni, Ana Bujan, Maria C Carrillo, Andrzej Cichocki, Jaisalmer de Frutos-Lucas, Claudio Del Percio, Bruno Dubois, Rebecca Edelmayer, Gary Egan, Stephane Epelbaum, Javier Escudero, Alan Evans, Francesca Farina, Keith Fargo, Alberto Fernández, Raffaele Ferri, Giovanni Frisoni, Harald Hampel, Michael G Harrington, Vesna Jelic, Jaeseung Jeong, Yang Jiang, Maciej Kaminski, Voyko Kavcic, Kerry Kilborn, Sanjeev Kumar, Alice Lam, Lew Lim, Roberta Lizio, David Lopez, Susanna Lopez, Brendan Lucey, Fernando Maestú, William J McGeown, Ian McKeith, Davide Vito Moretti, Flavio Nobili, Giuseppe Noce, John Olichney, Marco Onofrj, Ricardo Osorio, Mario Parra-Rodriguez, Tarek Rajji, Petra Ritter, Andrea Soricelli, Fabrizio Stocchi, Ioannis Tarnanas, John Paul Taylor, Stefan Teipel, Federico Tucci, Mitchell Valdes-Sosa, Pedro Valdes-Sosa, Marco Weiergräber, Gorsev Yener, Bahar Guntekin

    Measures of Resting State EEG Rhythms for Clinical Trials in Alzheimer’s Disease Patients: Recommendations of an Expert Panel

  • Jul

    2021

    PLoS computational biology

    doi: 10.1371/journal.pcbi.1009129

    Hashemi M, Vattikonda AN, Sip V, Diaz-Pier S, Peyser A, Wang H, Guye M, Bartolomei F, Woodman MM, Jirsa VK

    On the influence of prior information evaluated by fully Bayesian criteria in a personalized whole-brain model of epilepsy spread

  • May

    2021

    eNeuro

    doi: 10.1523/ENEURO.0475-20.2021

    Arbabyazd L, Shen K, Wang Z, Hofmann-Apitius M, Ritter P, The Alzheimer’s Disease Neuroimaging Initiative, McIntosh AR, Battaglia D, Jirsa V

    Virtual connectomic datasets in Alzheimer’s Disease and aging using wholebrain network dynamics modelling

  • Mar

    2021

    BioRxiv

    doi: 10.1101/2021.02.27.433161

    Triebkorn P, Stefanovski L, Dhindsa K, Diaz-Cortes M, Bey P, Bülau K, Kalsank Pai R, Spiegler A, Solodkin A, Jirsa V, McIntosh R, Ritter P, Alzheimer's Disease Neuroimaging Initiative

    Multi-scale brain simulation with integrated positron emission tomography yields hidden local field potential activity that augments machine-learning classification of Alzheimer's disease

  • Feb

    2021

    arXiv

    arXiv:2102.05888

    M. Schirner, L. Domide, D. Perdikis, P. Triebkorn, L. Stefanovski, R. Pai, P. Popa, B. Valean, J. Palmer, C. Langford, A. Blickensdörfer, M. van der Vlag, S. Diaz-Pier, A. Peyser, W. Klijn, D. Pleiter, A. Nahm, O. Schmid, M. Woodman, L. Zehl, J. Fousek, S. Petkoski, L. Kusch, M. Hashemi, D. Marinazzo, J.-F. Mangin, A. Flöel, S. Akintoye, B. C. Stahl, M. Cepic, E. Johnson, G. Deco, A. R. McIntosh, C. C. Hilgetag, M. Morgan, B. Schuller, A. Upton, C. McMurtrie, T. Dickscheid, J. G. Bjaalie, K. Amunts, J. Mersmann, V. Jirsa, P. Ritter

    Brain Modelling as a Service: The Virtual Brain on EBRAINS

  • Dec

    2020

    Cerebral Cortex

    doi: 10.1093/cercor/bhaa339

    Klein PC, Ettinger U, Schirner M, Ritter P, Rujescu D, Falkai P, Koutsouleris N, Kambeitz-Ilankovic L, Kambeitz J

    Brain Network Simulations Indicate Effects of Neuregulin-1 Genotype on Excitation-Inhibition Balance in Cortical Dynamics

  • Nov

    2020

    Front. Neuroinform

    doi: 10.3389/fninf.2021.630172

    Stefanovski L, Meier JM, Pai R, Triebkorn P, Lett T, Martin L, Bülau K, Hofmann-Apitius M, Solodkin A, McIntosh A, Ritter P

    Bridging Scales in Alzheimer's Disease: Biological Framework for Brain Simulation With The Virtual Brain

  • Sep

    2020

    Springer, New York, NY

    doi: 10.1007/978-1-4614-7320-6

    Viktor Jirsa, Marmaduke Woodman, Lia Domide

    The Virtual Brain (TVB): Simulation Environment for Large-Scale Brain Networks

  • Jul

    2020

    Front Cell Neurosci.

    doi:10.3389/fncel.2020.00240

    Palesi F, Lorenzi RM, Casellato C, Ritter P, Jirsa V, Gandini Wheeler- Kingshott CAM, D'Angelo E.

    The Importance of Cerebellar Connectivity on Simulated Brain Dynamics

  • Jul

    2020

    J Neurosci.

    doi:10.1523/JNEUROSCI.0905-19.2020

    Courtiol J, Guye M, Bartolomei F, Petkoski S, Jirsa VK.

    Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy

  • Mar

    2020

    Neuroimage

    doi:10.1101/752931

    Aerts H, Schirner M, Hollander T, Jeurissen B, Achten E, Van Roost D, Ritter P, Marinazzo D

    Modeling brain dynamics after tumor resection using The Virtual Brain

  • Mar

    2020

    BioRxiv

    doi: 10.1101/2020.03.26.009795

    Triebkorn P, Zimmermann J, Stefanovski L, Roy D, Solodkin A, Jirsa V, Deco G, Breakspear M, McIntosh AR, Ritter P

    Identifying optimal working points of individual Virtual Brains: A large-scale brain network modelling study

  • Dec

    2019

    PNAS

    doi:10.1073/pnas.1906694116

    Melozzi F, Bergmann E, Harris JA, Kahn I, Jirsa V, Bernard C

    Individual structural features constrain the mouse functional connectome

  • Dec

    2019

    Network Neuroscience

    doi:10.1162/netn_a_00120

    Ryan JD, Shen K, Kacollja A, Tian H, Griffiths J, Bezgin G, McIntosh AR

    Modeling the influence of the hippocampal memory system on the oculomotor system

  • Oct

    2019

    Computational Brain & Behaviour

    doi:10.1007/s42113-019-00062-x

    Poldrack RA, Feingold F, Frank MJ, Gleeson P, de Hollander G, Huys QJM, Love BC, Markiewicz CJ, Moran R, Ritter P, Rogers TT, Turner BM, Yarkoni T, Zhan M, Cohen JD

    The Importance of Standards for Sharing of Computational Models and Data

  • Aug

    2019

    Network Neuroscience

    doi:10.1162/netn_a_00107

    McIntosh AR, Jirsa VK

    The hidden repertoire of brain dynamics and dysfunction

  • Jul

    2019

    Nature Scientific Data

    doi: 10.1038/s41597-019-0129-z

    Shen K, Bezgin G, Schirner M, Ritter P, Everling S, McIntosh AR

    A macaque connectome for large-scale network simulations in The Virtual Brain

  • Jun

    2019

    PLoS Comput Biol.

    doi:10.1371/journal.pcbi.1007051

    An S, Bartolomei F, Guye M, Jirsa V

    Optimization of surgical intervention outside the epileptogenic zone in the Virtual Epileptic Patient (VEP)

  • May

    2019

    Frontiers Computational Neuroscience

    doi:10.3389/fncom.2019.00054

    Stefanovski L, Triebkorn P, Spiegler A, Diaz-Cortes MA, Solodkin A, Jirsa VK, McIntosh AR, Ritter P, The Alzheimer's Disease Neuroimaging Initiative

    Linking molecular pathways and large-scale computational modeling to assess candidate disease mechanisms and pharmacodynamics in Alzheimer's disease

  • Sep

    2018

    Neurophysiologie Clinique

    doi:10.1016/j.neucli.2018.06.036

    Jirsa VK, Sip V

    On generalized notions of the Epileptogenic Zone

  • May

    2018

    Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research; Elsevier

    doi:10.1016/B978-0-12-804078-2.00001-5

    Solodkin A, Zimmermann J, McIntosh AR, Stefanovski L, Ritter P

    Neurological Biomarkers and Neuroinformatics: The Role of The Virtual Brain

  • Mar

    2018

    Nature Communications

    doi:10.1038/s41467-018-02973-y

    Proix T, Jirsa VK, Bartolomei F, Guye M, Truccolo W

    Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy

  • Mar

    2018

    Neuroimage Clinical

    doi:10.1101/277624

    Zimmermann J, Perry A, Breakspear M, Schirner, Sachdev P, Wen W, Kochan NA, Capstone M, Ritter P, McIntosh AR, Solodkin A

    Differentiation of Alzheimer’s disease based on local and global parameters in personalized Virtual Brain models

  • Mar

    2018

    Network Neuroscience

    doi:10.1101/277590

    Zimmermann J, Griffiths J, Schirner M, Ritter P, McIntosh AR

    Subject-specificity of the correlation between large-scale structural and functional connectivity

  • Feb

    2018

    eNeuro

    doi:10.1101/265637

    Aerts H, Schirner M, Jeurissen B, Van Roost D, Achten E, Ritter P, Marinazzo D

    Modeling brain dynamics in brain tumor patients using The Virtual Brain

  • Jan

    2018

    eLife 2018

    doi:10.7554/eLife.28927

    Schirner M, McIntosh AR, Jirsa V, Deco G, Ritter P

    Inferring multi-scale neural mechanisms with brain network modelling

  • Jul

    2017

    NeuroImage

    doi.org/10.1016/j.neuroimage.2017.07.046

    Díaz-Parra A, Osborn Z, Canals S, Moratal D, Sporns O

    Structural and functional, empirical and modeled connectivity in the cerebral cortex of the rat

  • Jun

    2017

    eNeuro

    doi.org/10.1523/ENEURO.0111-17.2017

    Melozzi F, Woodman MM, Jirsa VK and Bernard C

    The Virtual Mouse Brain: A Computational Neuroinformatics Platform to Study Whole Mouse Brain Dynamics

  • Jun

    2017

    Scientific Reports, 7: 3095

    doi:10.1038/s41598-017-03073-5

    Deco G, Kringelbach ML, Jirsa VK & Ritter P

    The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

  • May

    2017

    Neuron

    doi.org/10.1016/j.neuron.2017.05.013

    Pillai AS and Jirsa VK

    Symmetry Breaking in Space-Time Hierarchies Shapes Brain Dynamics and Behaviour

  • Apr

    2017

    bioRxiv

    doi:10.1101/123406

    Melozzi F, Woodman MM, Jirsa VK, Bernard C

    The Virtual Mouse Brain: a computational neuroinformatics platform to study whole mouse brain dynamics

  • Feb

    2017

    Brain, 2017

    doi:10.1093/awx018

    Proix T, Bartolomei F, Guye M, Jirsa VK

    Individual brain structure and modelling predict seizure propagation

  • Feb

    2017

    Human Brain Mapping, 2017

    doi:10.1002/hbm.23506

    Bezgin G, Solodkin A, Bakker, Ritter P, McIntosh AR

    Mapping complementary features of cross-species structural connectivity to construct realistic "Virtual Brains"

  • Nov

    2016

    Neuroimage, 2016

    doi: 10.1016/j.neuroimage.2016.06.016

    Prix T, Spiegler A, Schirner M, Rothmeier S, Ritter P, Jirsa VK

    How do parcellation size and short-range connectivity affect dynamics in large-scale brain network models?

  • Sep

    2016

    e-Neuroforum, 2016

    doi:10.1007/s13295-016-0027-1

    Stefanovski L, Ghani A, McIntosh AR, Ritter P

    Linking connectomics and dynamics in the human brain: Big data need big theories!

  • Apr

    2016

    Neuroimage, 2016

    doi:10.1016/j.neuroimage.2016.04.049

    Jirsa VK, Proix T, Perdikis D, Woodman MM, Wang H, Gonzalez-Martinez J, Bernard C, Bénar C, Guye M, Chauvel P, Bartolomei F

    The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread

  • Mar

    2016

    eneuro. Mar 2016;3(2)

    doi:10.1523/ENEURO.0158-15.2016

    Falcon MI, Riley JD, Jirsa VK, McIntosh AR, Shereen AD, Chen EE, Solodkin A

    Functional mechanisms of recovery after chronic stroke: modelling with The Virtual Brain

  • Feb

    2016

    Neuroimage, 2016

    doi:10.1016/j.neuroimage.2016.02.015

    Kunze T, Hunold A, Haueisen J, Jirsa VK, Spiegler A

    Transcranial direct current stimulation changes resting state functional connectivity: A large-scale brain network modelling study

  • Nov

    2015

    Front Neurol. 2015 Nov 2;6:228

    doi:10.3389/fneur.2015.00228. eCollection 2015. PubMed PMID: 26579071; PubMed Central PMCID: PMC4629463

    Falcon MI, Riley JD, Jirsa V, McIntosh AR, Shereen AD, Chen EE, Solodkin A

    The Virtual Brain: Modeling Biological Correlates of Recovery after Chronic Stroke

  • Nov

    2015

    Front Neuroinform. 2015 Nov 25;9:27

    doi: 10.3389/fninf.2015.00027. eCollection 2015. PubMed PMID: 26635597; PubMed Central PMCID: PMC4658631

    Matzke H, Schirner M, Vollbrecht D, Rothmeier S, Llarena A, Rojas R, Triebkorn P, Domide L, Mersmann J, Solodkin A, Jirsa VK, McIntosh AR, Ritter P

    TVB-EduPack - An Interactive Learning and Scripting Platform for The Virtual Brain

  • Aug

    2015

    PLoS Computational Biology

    doi:10.1371/journal.pcbi.1004352

    Becker R, Knock S, Ritter P, Jirsa V

    Relating alpha power and phase to population firing and hemodynamic activity using a thalamo-cortical neural mass model

  • Aug

    2015

    Neuroimage, 2015 Aug 15;117:343-357

    doi:10.1016/j.neuroimage.2016.03.055

    Schirner M, Rothmeier S, Jirsa VK, McIntosh AR, Ritter P

    An automated pipeline for constructing personalized virtual brains from multimodal neuroimaging data

  • Jul

    2015

    Trends in Cognitive Science, 19(10): 616-628

    doi:10.1016/j.tics.2015.07.011

    Kringelbach M, McIntosh AR, Ritter P, Jirsa V, Deco G.

    The rediscovery of slowness: exploring the timing of cognition

  • Jun

    2015

    J Neurosci. 2015 Jun 10;35(23):8914-24

    doi: 10.1523/JNEUROSCI.4560-14.2015. PubMed PMID: 26063923; PubMed Central PMCID: PMC4589568

    Adhikari MH, Raja Beharelle A, Griffa A, Hagmann P, Solodkin A, McIntosh AR, Small SL, Deco G

    Computational modeling of resting-state activity demonstrates markers of normalcy in children with prenatal or perinatal stroke

  • Jun

    2015

    Front Comput Neurosci. 2015 Jun 23;9:77

    doi: 10.3389/fncom.2015.00077. eCollection 2015. PubMed PMID: 26157384; PubMed Central PMCID: PMC4477138

    Ritter P, Jirsa VK, McIntosh AR, Breakspear M

    Editorial: State-dependent brain computation

  • May

    2015

    Neuroimage. 2015 May 1;111:385-430

    doi: 10.1016/j.neuroimage.2015.01.002. Epub 2015 Jan 13. PubMed PMID: 25592995

    Sanz-Leon P, Knock SA, Spiegler A, Jirsa VK

    Mathematical framework for large-scale brain network modeling in The Virtual Brain

  • Dec

    2014

    Brain Connect. 2014 Dec;4(10):791-811

    doi:10.1089/brain.2014.0252. PubMed PMID: 25131838

    Roy D, Sigala R, Breakspear M, McIntosh AR, Jirsa VK, Deco G, Ritter P

    Using The Virtual Brain to reveal the role of oscillations and plasticity in shaping brain's dynamical landscape

  • Mar

    2014

    Front Comput Neurosci 8: 36

    doi:10.3389/fncom.2014.00036

    Sigala, R, Haufe S, Roy D, Dinse HR, Ritter P.

    The role of alpha-rhythm states in perceptual learning: insights from experiments and computational models

  • Mar

    2014

    Front. Neuroinform. 8:36

    doi: 10.3389/fninf.2014.00036

    Woodman MM, Pezard L, Domide L, Knock S, Sanz Leon P, Mersmann J, McIntosh AR, Jirsa VK

    Integrating Neuroinformatics Tools in The Virtual Brain

  • Jun

    2013

    Neuroimage. 2013 Jun 3;83:704-725

    doi:10.1016/j.neuroimage.2013.06.018

    Spiegler A, Jirsa VK

    Systematic approximations of neural fields through networks of neural masses in The Virtual Brain

  • Apr

    2013

    Brain Connect 3(2): 121-145

    doi:10.1089/brain.2012.0120

    Ritter, P., M. Schirner, A. R. McIntosh and V. K. Jirsa

    The Virtual Brain integrates computational modeling and multimodal neuroimaging